Peril of pleasure

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Here, we use the RDoC conceptualization to review research on threat responses, reward processing, and their interaction. The first section of the manuscript highlights the pivotal role of exaggerated threat responses-mediated by circuits connecting the frontal cortex, amygdala, and midbrain-in anxiety, and reviews data indicating that genotypic variation in the serotonin system is associated with hyperactivity in this circuitry, which elevates the risk for anxiety and mood disorders. The third section covers recent studies that document negative effects of acute threats and chronic stress on reward responses in humans.

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Skip to search form Skip to main content. Peril and pleasure: an rdoc-inspired examination of threat responses and reward processing in anxiety and depression. Dillon and Isabelle M.

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Skip to search form Skip to main content. Dillon and Isabelle M. Rauch and Diego A.

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Here, we use the RDoC conceptualization to review research on threat responses, reward processing, and their interaction. The first section of the manuscript highlights the pivotal role of exaggerated threat responses—mediated by circuits connecting the frontal cortex, amygdala, and midbrain—in anxiety, and reviews data indicating that genotypic variation in the serotonin system is associated with hyperactivity in this circuitry, which elevates the risk for anxiety and mood disorders. The third section covers recent studies that document negative effects of acute threats and chronic stress on reward responses in humans.

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If you believe that digital publication of certain material infringes any of your rights or privacy interests, please let the Library know, stating your reasons. You will be contacted as soon as possible. In the second part of this thesis, we focus on effects of oxytocin administration on reward processing and functional connectivity networks in PTSD.

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Stephanie Stokes Oliver invites the reader into a black magic circle of incendiary, replenishing and inspiring ideas, memories and meditations on the power of literacy and imagination by the writers we treasure. It was a pleasure to re-read established classics and discover new classic arguments for the power of the written and read word. Washington's piece: 'A Whole Race Begins to Read' about the eagerness with which former enslaved persons strove to educate themselves, after the Civil War, well, just the thought of it, might bring us to our knees. We were liberated by literacy!

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