Familial breast cancer

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Steven Narodis a world leader in the study of inherited cancers. With a particular focus on breast and ovarian cancers, Dr. Through its extensive research, publications, data collection, genetic testing programs and collaborations, the team has become an internationally renowned leader in identifying and developing effective strategies to prevent and manage these cancers women and families with a high inherited risk.

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Mutations in known breast cancer genes such as BRCA1 and BRCA2 are identified in only approximately 20 per cent of women who are offered genetic testing for familial breast cancer. Researchers at the University of Melbourne, led by Professor Melissa Southey, looked at people from 25 multiple-case breast cancer families. They identified 24 previously unknown epigenetic changes that alter a woman's risk of breast cancer and can be passed down through generations without involving changes in the DNA sequence of genes.

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Genes contain the information that determines how our cells grow and work throughout our lifetime. This information can be passed from one generation to the next inherited. This can cause the cells to grow out of control, leading to cancer.

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People have the right to be involved in discussions and make informed decisions about their care, as described in your care. Making decisions using NICE guidelines explains how we use words to show the strength or certainty of our recommendations, and has information about prescribing medicines including off-label useprofessional guidelines, standards and laws including on consent and mental capacityand safeguarding. Jewish ancestry [ 1 ]. Patients should have the opportunity to make informed choices about any treatment and care and to share in decision making.

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This guideline covers care for people with a family history of breast, ovarian or another related prostate or pancreatic cancer. It aims to improve the long-term health of these families by describing strategies to reduce the risk of and promote early detection of breast cancer including genetic testing and mammography. It also includes advice on treatments tamoxifen, raloxifene and surgery mastectomy.

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A risk factor is anything that affects your chance of getting a disease, such as breast cancer. But having a risk factor, or even many, does not mean that you are sure to get the disease. Some risk factors for breast cancer are things you cannot change, such as being a woman, getting older, and having certain gene changes.

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Genetic testing is available in specialised laboratories, but is expensive and presents a significant technical and interpretative challenge. Identification of a causative mutation carries lifelong health and psychosocial implications for the woman and her relatives. It also influences surveillance and treatment options.

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This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources.

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What to do if you're concerned about your family history 2. Your family history risk assessment appointment 3. Different levels of breast cancer risk 4.

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If you have close relatives with breast or ovarian cancer, you may be at higher risk for developing these diseases. Does your family health history put you at higher risk? Would you benefit from cancer genetic counseling and testing? Each year, aboutwomen in the United States are diagnosed with breast cancer and more than 21, are diagnosed with ovarian cancer.


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